Searchable Databases
Psychedelics & Pain Database
Autoimmune & Inflammation Database
Psychedelics & Pain Database
Research since the 1930’s into the analgesic effects of psychedelics has shown potential across a wide range of compounds and conditions. Through several proposed mechanisms of actions, from neurological to psychological, psychedelic medicines have been shown to have powerful pain reducing effects across a wide variety of conditions. Data continues to mount in research trials across the globe. Search the database below for pain conditions and keep scrolling for the Autoimmune and Inflammation database.
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Psychedelics, Inflammation, & Autoimmune Database
Year | Title | Compound | Condition | Journal | Author |
---|---|---|---|---|---|
2013 | Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo. | (R)-DOI | Inflammation | PloS one | Nau Jr, F., Yu, B., Martin, D. and Nichols, C.D. |
2015 | Psychedelics and immunomodulation: novel approaches and therapeutic opportunities. | Classic psychedelics, DMT, LSD, MDMA | Immunomodulation | Frontiers in immunology | Szabo, A. |
2017 | Psychedelics as medicines: an emerging new paradigm. | Serotonergic psychedelics, Classic psychedelics, 5-HT2A receptor agonists. psilocybin, LSD | Clinical Pharmacology & Therapeutics | Nichols, D.E., Johnson, M.W. and Nichols, C.D. | |
2017 | Psychedelic drugs in biomedicine. | Classic psychedelics, LSD, psilocybin | Trends in pharmacological sciences | Kyzar, E.J., Nichols, C.D., Gainetdinov, R.R., Nichols, D.E. and Kalueff, A.V. | |
2018 | Psychedelics as anti-inflammatory agents. | (R)-DOI, 5-HT2A agonists, Classic psychedelics | Inflammation | International Review of Psychiatry | Flanagan, T.W. and Nichols, C.D. |
2018 | The effects of hallucinogens on gene expression. | Serotonergic psychedelics, Classic psychedelics, 5-HT2A receptor agonists. psilocybin, LSD | Gene expression | Behavioral Neurobiology of Psychedelic Drugs | Martin, D.A. and Nichols, C.D. |
2019 | Effects of psychedelics on inflammation and immunity. | LSD, psilocybin, MDMA, ayahuasca, classic psychedelics, cannabidiol, DMT | Inflammation, Immunity | Advances in psychedelic medicine: state-of-the-art therapeutic applications | Szabo, A. |
2019 | 5-HT2 receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model. | (R)-DOI | Airway inflammation, Asthma | Life Sciences | Flanagan, T.W., Sebastian, M.N., Battaglia, D.M., Foster, T.P., Cormier, S.A. and Nichols, C.D. |
2019 | Activation of 5-HT2 receptors reduces inflammation in vascular tissue and cholesterol levels in high-fat diet-fed apolipoprotein E knockout mice. | (R)-DOI | Inflammation, vascular, cholesterol | Scientific Reports | Flanagan, T.W., Sebastian, M.N., Battaglia, D.M., Foster, T.P., Maillet, E.L. and Nichols, C.D. |
2019 | Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. | Microdose, Microdosing, Classic psychedelics | Journal of Psychopharmacology | Kuypers, K.P., Ng, L., Erritzoe, D., Knudsen, G.M., Nichols, C.D., Nichols, D.E., Pani, L., Soula, A. and Nutt, D. | |
2020 | Structure–activity relationship analysis of psychedelics in a rat model of asthma reveals the anti-inflammatory pharmacophore. | 2C-H | ACS Pharmacology & Translational Science | Flanagan, T.W., Billac, G.B., Landry, A.N., Sebastian, M.N., Cormier, S.A. and Nichols, C.D. | |
2020 | 5‐HT2 Receptor Activation Differentially Modulates Linker Histone Kinetics and Histone Deacetylase Activity. | (R)-DOI, psilocin | Linker Histone Kinetics, Histone Deacetylase Activity | The FASEB Journal | Flanagan, T.W., Billac, G.B. and Nichols, C.D. |
2020 | Psychedelics as a novel approach to treating autoimmune conditions. | Classic psychedelics | Immunology Letters | Thompson, C. and Szabo, A. | |
2021 | The DMT and psilocin treatment changes CD11b+ activated microglia immunological phenotype. | DMT, psilocin | BioRXiv | Kozłowska, U., Klimczak, A., Wiatr, K. and Figiel, M. | |
2021 | Associations between lifetime classic psychedelic use and cardiometabolic diseases. | Classic psychedelics | Cardiometabolic Disease | Scientific Reports | Simonsson, O., Osika, W., Carhart-Harris, R. and Hendricks, P.S. |
2021 | Pharmahuasca Reduces ROS Production and inflammatory Gene Expression in the Brain in a Model of PTSD: Exploration by RNA Sequencing. | Pharmahuasca | Gene expression | ACS Chemical Neuroscience | Kelley, D.P., Venable, K., Billac, G., Destouni, A., Ebenezer, P., Stadler, K., Nichols, C., Barker, S. and Francis, J. |
2022 | Psilocybin induces acute and persisting alterations in immune status and the stress response in healthy volunteers. | Psilocybin | Immune status, stress response | medRxiv | Mason, N.L., Szabo, A., Kuypers, K.P., Mallaroni, P.A., de la Torre, R., Reckweg, J.T., Tse, D.H., Hutten, N.R., Feilding, A. and Ramaekers, J.G. |
2022 | From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders. | Classic psychedelics, psychedelics | Neurodegenerative disorders | Journal of Neurochemistry | Kozlowska, U., Nichols, C., Wiatr, K. and Figiel, M. |
2022 | Differential Regulation of Inflammatory Responses Following 5‐HT2 Receptor Activation in Pulmonary Tissues. | (R)-DOI | Inflammation | The FASEB Journal, 36. | Flanagan, T.W., Billac, G. and Nichols, C.D. |
2022 | Psychedelics as potent anti-inflammatory therapeutics. | Classic psychedelics, psychedelics | Inflammation | Neuropharmacology | Nichols, C.D. |
2022 | Psychedelics and anti-inflammatory activity in animal models. | (R)-DOI, psilocybin | Inflammation | In Disruptive Psychopharmacology | Flanagan, T.W. and Nichols, C.D. |
2023 | Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders. | Psilocybin | Neuropharmacology | Wulff, A.B., Nichols, C.D. and Thompson, S.M. | |
2023 | Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation. | Psilocybin | Comprehensive Psychoneuroendocrinology | Burmester, D.R., Madsen, M.K., Szabo, A., Aripaka, S.S., Stenbæk, D.S., Frokjaer, V.G., Elfving, B., Mikkelsen, J.D., Knudsen, G.M. and Fisher, P.M. | |
Year | Title | Compound | Condition | Journal | Author |